Dayna Devon shows off her good looks. Photo courtesy of Allergan

Spending ten years interviewing the world's biggest celebrities on "Extra" taught Dayna Devon a thing or two.

Specifically, it taught her that when it comes to nips and tucks, everybody's doing it.

"I'm a big fan of reading old literature, like Jane Austen," Devon told us. "In those days, when you aged, you were kind of S.O.L."

The Texas-born TV host moved to Hollywood for her Extra gig, and her easy-going personality and star-quality looks earned her much success. Not to mention the affection of a plastic surgeon, Dr. Brent Moelleken, whom Devon ended up marrying.

"He introduced me to fillers," said Devon, who has now signed on to be a spokesperson for Allergan, the maker of popular line and wrinkle filler Juvederm. "I just think it's great that we have these options now," she explained. "I love them!"

Devon isn't shy about chatting revealing what she's had done, and doesn't understand why things have to be so hush-hush.

"Members of the [Extra] crew would knock on my door and whisper 'I have to ask you a question. What about this? Or this?'" Luckily for the crew, Devon openly dispensed advice based on her experience. "I've had these lines done [she gestures to the nose-to-mouth lines] and Botox," she reveals.

While we wouldn't be surprised if Devon's perfectly chiseled facial features were the result of more invasive procedures, she insists she sticks to the temporary ones, like aforementioned Juvederm and eyelash extensions.

"You wake up in the morning and they're like, bing! You go to the gym and they're like bing!" she laughs at her foray into doe-eyed-ness.

But how safe are these procedures, really?

"It's very important that you see a trained specialist, not someone who just learned how to do it from a YouTube video," says Michelle, an eyelash extension tech at New York City's Uptown Girl salon, where stars like "The View" host Elizabeth Hasselbeck and fashion designer Betsey Johnson have stopped by for lash extensions.

As for fillers, Juvéderm is made from hyaluronic acid, which occurs naturally in the body so there's no risk of allergic reaction. The substance is injected into lines and wrinkles to plump up the area for up to one year, after which it's simply absorbed back into the body's own supply. And there's good news for fans: A new formula, Juvéderm XC, contains numbing agent lidocaine to make injections less painful.

Botox is made from botulinum toxin, which may sounds scary, but the substance has been widely used for cosmetic purposes in the U.S. since 2002, and elsewhere for over a decade. "The good news is, it's not permanent. The bad news is, it's not permanent," says NYC plastic surgeon Dr. Gerald Imber, who notes that most women who try it come back for more.

http://www.stylelist.com/2010/03/19/tv-host-dayna-devon-reveals-her-nips-and-tucks/

New Data Published by Journal of American Academy of Dermatology Demonstrated Sustained Efficacy Up to 25 Months

Bridgewater, N.J. – February 23, 2010 -- Results published in today’s online issue of the Journal of American Academy of Dermatology showed that treatment with Sculptra^®Aesthetic (injectable poly-L-lactic acid) was significantly more effective than a human-derived collagen treatment CosmoPlast^®* in correcting shallow to deep nasolabial fold (NLF) wrinkles (smile lines). In addition, this study demonstrated that the effect in correcting the NLF wrinkles with SculptraAesthetic can last for up to 25 months.

A total of 233 patients of ages ranging from 26 to 73 years were randomized to receive injections of either SculptraAesthetic (n=116) or CosmoPlast (n=117) (standard of care at study initiation) into the left and right nasolabial folds at three-week intervals for up to a maximum of four treatments and followed for 13 months after the final treatment. Treatment with SculptraAesthetic resulted in significantly (P<0.001) higher scores than CosmoPlast on the Wrinkle Assessment Scale, a validated photographic measurement tool which is used to assess the NLF wrinkles at week three, and months three, six, nine and 13 during the follow up phase of the study. The SculptraAesthetic patients were followed for an additional 12 months. SculptraAesthetic treatment effects were maintained up to 25 months after the last treatment session, while the human derived collagen was effective up to three months.

“This study established that SculptraAesthetic offers significant improvements in correcting nasolabial folds, which are considered one of the signs of facial aging,” said Dr. Gary Monheit, Associate Clinical Professor, Department of Dermatology, University of Alabama Medical Center, “We found that the treatment works gradually to replace lost collagen due to aging, resulting in a more natural-looking appearance that can last up to two years.”

The majority of adverse events in both groups were mild or moderate in intensity; these included injection site reactions such as bleeding, tenderness or pain/discomfort, redness, bruising, itching or swelling. During the initial 13 month follow up, product-related application site nodules occurred in 8.6 percent of patients treated with SculptraAesthetic and 9.4 percent of those patients receiving CosmoPlast; papules occurred in 8.6 percent of patients in the SculptraAesthetic group versus 3.4 percent of patients treated with CosmoPlast.

In addition, after 25 months papules and nodules were reported in Sculptra Aesthetic treatment group in 1.9% and 0.9% of patients, respectively. Papules and nodules were typically palpable, asymptomatic and non-visible.  The majority of nodule and papule events were mild to moderate and most resolved without treatment. Overall, a higher incidence of adverse events was recorded among patients in the collagen group (63.2 percent) compared with patients treated with SculptraAesthetic (53.4 percent). No patient discontinued treatment with SculptraAesthetic due to a treatment-related adverse event.

Study Design

In the randomized, comparative, evaluator-blinded, parallel group, multi-center study, 233 patients received either SculptraAesthetic or an approved human derived collagen for the treatment of their nasolabial fold wrinkles. SculptraAesthetic was administered in a single treatment regimen, at three week intervals, for up to four treatment sessions for the correction of shallow to deep nasolabial fold contour deficiencies. The SculptraAesthetic patients were followed for an additional 12 months. In the comparative phase, the patients were followed for 13 months after the last treatment.

The study reports on the results of the primary efficacy and safety objectives. The primary efficacy objective evaluated the degree of correction of the nasolabial fold wrinkles attained by SculptraAesthetic compared with CosmoPlast based on Wrinkle Assessment Scale scores. Assessments were calculated at screening, three weeks after treatment and at three, six, nine and 13 months post-treatment. The primary safety endpoint was the overall incidence of adverse events reported during the 13-month follow-up period after treatment.

The study’s secondary objectives included global investigator and subject evaluations of treatment, patient treatment satisfaction scores, time to peak correction and treatment success rates.

Following the comparative treatment phase of the trial, patients treated with SculptraAesthetic were evaluated for an additional 12 months during a long-term surveillance phase to collect further safety and efficacy data. These patients were scheduled to return for follow-up visits 19 and 25 months after their final treatment during the study.

Important Safety Information:

You should not use Sculptra Aesthetic if you are allergic to any ingredient of the product or have a history of keloid formation or hypertrophic scarring.  Sculptra Aesthetic should not be injected while you have an active skin infection or inflammation in the treatment area and should not be injected into the red area of the lip. Use in the skin near the eyes is not recommended.

Side effects of Sculptra Aesthetic may include injection site discomfort, redness, bruising, bleeding, itching and swelling. Other side effects may include small lumps under the skin that are sometimes noticeable when pressing on the treated area.  Larger lumps, some with delayed onset with or without inflammation or skin discoloration, have also been reported.  In a key clinical study the numbers of small and larger lumps were low and most resolved without treatment.

About Sculptra® Aesthetic

SculptraAesthetic was approved by the U.S. Food and Drug Administration July 28, 2009 for use in people with healthy immune systems as one-time treatment regimen of up to 4 injection sessions that are scheduled about 3 weeks apart for correction of shallow to deep nasolabial fold contour deficiencies and other facial wrinkles in which deep dermal grid pattern (cross-hatch) injection technique is appropriate. Sculptra Aesthetic may provide cosmetic correction of facial wrinkles with a Wrinkle Assessment Score of 2, 3, or 4 as shown in the photos in Figure 1 of the full prescribing information for Sculptra Aesthetic.

No one likes looking older...which is why we spend billions of dollars every year on over-the-counter products, prescription creams and fillers, and, most drastically, cosmetic surgery. Do any of these actually work to reduce the signs of aging? In many cases, yes—at least temporarily. But given the not-inconsiderable costs (and in the case of surgery and some procedures, the risks), it's important to be smart in your choices.
How to find a doctor? Dermatologists can prescribe skin creams and perform laser skin-resurfacing and chemical peels, and they can administer injections. Surgical procedures, meantime, can be performed by cosmetic and plastic surgeons, and some ear, nose, and throat doctors (otolaryngologists). A good first step is to make sure that the doctor is board-certified by the appropriate organization (the American Board of Cosmetic Surgery, the American Board of Plastic Surgery, and American Board of Otolaryngology, for instance). Check with your state medical board to see if the doctor has complaints on file. When you pick a doctor, ask how often and how frequently he or she performs the procedure that you're having (weekly is better than monthly). If the doc works from an outpatient surgical center, ask whether he or she has hospital privileges should any problems arise during your surgery.
Here is a quick guide to some of the most popular treatments and procedures.

1. Retinoid creams
A host of over-the-counter products claim to help fight wrinkles. One option: topical retinoid (derived from vitamin A) creams; look for retinol in the ingredient list. "They're the only thing that's been proven to get rid of wrinkles that you already have," says Leslie Baumann, a Miami Beach dermatologist in private practice and the author of The Skin Type Solution: A Revolutionary Guide to Your Best Skin Ever. You can buy an OTC retinoid for under $20. Dermatologists can prescribe stronger retinoid creams—like Retin-A—than what you'll find on store shelves.